This version (2025/01/07 10:08) was approved by manos.papadopoulos.The Previously approved version (2021/07/26 08:54) is available.Diff

Table of Contents

Northern Lincolnshire and Goole NHS Foundation Trust - Nuclear Medicine

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SOP CodeTitleReview Date
REF002Radionuclide Ventriculography2028-01-07


Authorised By Authorising Role Authorisation Signature
(only on master paper copy) 		Date Authorised
Dr M Balerdi ARSAC Licence Holder 2025-01-07

REF002 - Radionuclide Ventriculography

See REF000 - Referring to Nuclear Medicine (NLAG) for details on how to refer.

Description

Radionuclide ventriculography (sometime referred to as a MUGA scan) is a reproducible technique for assessing left ventricular function and left ventricular ejection fraction. It is performed by in-vivo labelling of red cells with a radioactive tracer followed by acquiring ECG gated images on a gamma camera.

ARSAC Licence Holders
Dr Matt Balerdi
Prof Ged Avery
Dr Najeeb Ahmed


NuclidePharmaceutical FormLocal DRL (MBq)
Tc99mPertechnetate (after inactive stannous agent/PYP) 400


Typical Radiation Dose (mSv) 2.8mSv for 400MBq

Staff Entitled to Refer

  • All UK registered medical practitioners

Supplementary Drugs

  • Sodium chloride for parenteral use (0.9% w/v).
  • Stannous Agent/Sodium pyrophosphate.

Contraindications

  • Pregnancy.
  • Significant disturbance of cardiac rhythm, e.g. atrial fibrillation, and hence a highly variable RR interval, means gated imaging is unlikely to be reliable.

Clinical Indications

Assessment of global left ventricular function[1][2]
Assessment of regional left ventricular function/wall motion abnormalities[2]
Assessment of diastolic function[2]
Serial measurement of left ventricular ejection fraction to assess left ventricular function following administration of chemotherapeutic or other cardiotoxic agents (e.g.Herceptin) [1][2]
Suspected heart failure (e.g. selection of patients for ACE inhibitor) [1]
Assessment of ventricular function in patients with valvular heart disease [1]
Assessment of left ventricular function prior to major surgery
Assessment of left ventricular function prior to cardiac transplantation
Assessment of left-to-right cardiac shunts (via first pass imaging) [2]
Assessment of right ventricular function (via first pass imaging) [2]
[1] Nicol, A et al. Procedure Guideline for Planar Radionuclide Cardiac Ventriculogram for the Assessment of Left Ventricular Systolic Function. Version 2 2016. British Nuclear Medicine Society
[2] ACR–NASCI–SNMMI–SPR–STR Practice Parameter For The Performance of Cardiac Scintigraphy (Amended 2023)
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